HPV Genital Warts - The Guanacaste Study of HPV Natural History
Guanacaste Province is an area in Costa Rica with a very high incidence rate of cervical cancer. This prospective cohort study of HPV infection and cervical neoplasia is based on the recruitment and ongoing 7-year follow-up of a random sample of approximately 10,000 women 18+ years of age, residing in Guanacaste. The study is the companion to the prospective study of HPV and cervical neoplasia in Portland, which is a very low-risk, well-screened, mainly white middle-class U.S. population. Enrollment in 1993-1994 included a personal interview, cervical cytologic smears, Cervicography, cervical swabs for HPV, and a blood specimen. Participation was about 93% and all women with any screening abnormality were referred for colposcopy and biopsy. The prevalent phase of the study permitted several studies of HPV infection, cytology, Cervicography, and the whole spectrum of cervical neoplasia. The epidemiologic risk factors for each stage of neoplasia were identified, controlling for the central role of type-specific HPV infection. Follow-up of the cohort at six month to yearly intervals depending on disease status is now underway, to examine the origins of high-grade cervical intraepithelial neoplasia.
HPV Genital Warts - Vaccine Trial
A large randomized trial is planned in Costa Rica to evaluate the efficacy of two virus-like particle (VLP)-based prophylactic human papillomavirus (HPV) vaccines developed at NCI. Volunteers in the trial will be screened for cervical disease at entry and will receive three VLP or three placebo vaccinations over the course of six months. Participants will be actively followed for a period of four years and information will be collected on side effects of the vaccine (safety), immune induction by the vaccine (immunogenicity), and the occurence of cervical disease (efficacy).
HPV Genital Warts - Research Links:
Zanotti KM, Belinson J.
Update on the diagnosis and treatment of human papillomavirus infection.
Cleve Clin J Med. 2002 Dec;69(12):948, 951-5, 956 passim.
PMID: 12546268 [PubMed - in process]
Matsumoto K, Yoshikawa H, Yasugi T, Nakagawa S, Kawana K, Takeoka A, Yaegashi N, Iwasaka T, Kanazawa K, Taketani Y, Kanda T.
IgG antibodies to human papillomavirus 16, 52, 58, and 6 L1 capsids: Case-control study of cervical intraepithelial neoplasia in Japan.
J Med Virol. 2003 Mar;69(3):441-6.
PMID: 12526056 [PubMed - in process]
Boner W, Morgan IM.
Novel cellular interacting partners of the human papillomavirus 16 transcription/replication factor E2.
Virus Res. 2002 Dec;90(1-2):113-8.
PMID: 12457967 [PubMed - in process]
Akdeniz S, Yaldiz M, Akdeniz N.
Cervical biopsy specimens and human papilloma virus positivity in patients with external genital warts.
Eur J Gynaecol Oncol. 2002;23(5):460-2.
PMID: 12440827 [PubMed - in process]
Manhart LE, Koutsky LA.
Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis.
Sex Transm Dis. 2002 Nov;29(11):725-35. PMID: 12438912 [PubMed - indexed for MEDLINE]
Schwenger JU, von Buchwald C, Lindeberg H.
[Oral focal epithelial hyperplasia. Any risk of confusion with oral condylomas?]
Ugeskr Laeger. 2002 Sep 9;164(37):4287-90. Danish.
PMID: 12362871 [PubMed - indexed for MEDLINE]
Wiley DJ, Douglas J, Beutner K, Cox T, Fife K, Moscicki AB, Fukumoto L.
External genital warts: diagnosis, treatment, and prevention.
Clin Infect Dis. 2002 Oct 15;35(Suppl 2):S210-24.
PMID: 12353208 [PubMed - indexed for MEDLINE]
Svare EI, Kjaer SK, Worm AM, Osterlind A, Meijer CJ, van den Brule AJ.
Risk factors for genital HPV DNA in men resemble those found in women: a study of male attendees at a Danish STD clinic.
Sex Transm Infect. 2002 Jun;78(3):215-8.
PMID: 12238658 [PubMed - indexed for MEDLINE]
Sobhani I, Walker F, Aparicio T, Abramowitz L, Henin D, Cremieux AC, Soule JC.
Effect of anal epidermoid cancer-related viruses on the dendritic (Langerhans') cells of the human anal mucosa.
Clin Cancer Res. 2002 Sep;8(9):2862-9.
PMID: 12231528 [PubMed - indexed for MEDLINE]
Bleeker MC, Hogewoning CJ, Van Den Brule AJ, Voorhorst FJ, Van Andel RE, Risse EK, Starink TM, Meijer CJ.
Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia.
J Am Acad Dermatol. 2002 Sep;47(3):351-7.
PMID: 12196743 [PubMed - indexed for MEDLINE]
Buechner SA.
Common skin disorders of the penis. BJU Int. 2002 Sep;90(5):498-506. Review.
PMID: 12175386 [PubMed - indexed for MEDLINE]
Silverberg MJ, Ahdieh L, Munoz A, Anastos K, Burk RD, Cu-Uvin S, Duerr A, Greenblatt RM, Klein RS,Massad S, Minkoff H, Muderspach L, Palefsky J, Piessens E, Schuman P, Watts H, Shah KV.
The impact of HIV infection and immunodeficiency on human papillomavirus type 6 or 11 infection and on genital warts.
Sex Transm Dis. 2002 Aug;29(8):427-35.
PMID: 12172526 [PubMed - indexed for MEDLINE]
Ivanov S, Ivanov S.
[Large condylomatous lesions of the vulva and their malignant transformation]
Akush Ginekol (Sofiia). 2002;41(3):28-31. Bulgarian.
PMID: 12145975 [PubMed - indexed for MEDLINE]
Brentjens MH, Yeung-Yue KA, Lee PC, Tyring SK.
Human papillomavirus: a review.
Dermatol Clin. 2002 Apr;20(2):315-31. Review.
PMID: 12120445 [PubMed - indexed for MEDLINE]
Garland SM.
Human papillomavirus update with a particular focus on cervical disease.
Pathology. 2002 Jun;34(3):213-24. Review.
PMID: 12109780 [PubMed - indexed for MEDLINE]
Buffet M, Aynaud O, Piron D, Dupin N, Escande JP.
[Buschke-Lowenstein penile tumor]
Prog Urol. 2002 Apr;12(2):332-6. French.
PMID: 12108356 [PubMed - indexed for MEDLINE]
Williams OM, Hart KW, Wang EC, Gelder CM.
Analysis of CD4(+) T-cell responses to human papillomavirus (HPV) type 11 L1 in healthy adults reveals a high degree of responsiveness and cross-reactivity with other HPV types.
J Virol. 2002 Aug;76(15):7418-29.
PMID: 12097554 [PubMed - indexed for MEDLINE]
Berman B.
Imiquimod: a new immune response modifier for the treatment of external genital warts and other diseases in dermatology.
Int J Dermatol. 2002 May;41 Suppl 1:7-11. No abstract available.
PMID: 12087816 [PubMed - indexed for MEDLINE - hpv-genital warts
HPV Genital Warts - Medical Literature Review
Dr. Joe Glickman, Jr. is an accomplished medical author. He has made available a significant amount of research on HPV and genital warts which consists of many university studies. Since Dr. Glickman has spent over 20 years of his career writing medical books, he has been able to present complex information in a more simplified form that is easy to understand. Check out his website at www.health-science-report.com
to read more about HPV and genital warts.
